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KMID : 0043320010240010064
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Archives of Pharmacal Research
2001 Volume.24 No. 1 p.64 ~ p.68
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NMDA Receptor and NO Mediate ET-1-induced Behavioral an Cardiovascular Effects in Periaqueductal Gray Matter of Rats
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Ryu JS
Shin CY/Yang SJ/Lee TS/La HO/Song HU/Yom UK/Huh IH
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Abstract
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Endothelin-1 (ET-1), a novel and potent vasoconstrictor in blood vessel, is known to have some functions in the rat central nervous system (CNS). In order to investigate the cen tral functions of ET-1, ET-1 was administered to the periaqueductal gray area (PAG) of anesthetized rats to induce barrel rolling and increase the arterial blood pressure (ABP). ET-1 had amodulatory effect on central cardiovascular and behavioral control. The selective N-methyl-D-aspartate (NMDA) receptor antagonist MK-801 (3mcgmol/kg,I.p.) blocked the ET-1 induced responses, and both the nitric oxide synthase (NOS) inhibitor L-NAME (N-nitro-L-arginine ester 1 mmol/rat) and the nitric oxide (NO) scavenger hemoglobin (15nmol/rat) had similar effects in reducing the ET-1 (10 pmol/rat)-induced behavioral changes and ABP elevation. However, NO donor sodium nitroprusside (SNP 10mcg, 1mcg/rat) decreased the ET-1 induced ABP elevation, and recovered the ET-1-induced barrel rolling effect that was reduced by MK-801. These results suggest that ET-1 might have neuromodulatory functions such as ABP elevation and barrel rolling induction in the PAG of the rats via the rats via the NMDA receptor and NO.
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